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Kidney stone disease; Other names: Urolithiasis, kidney stone, renal calculus, nephrolith, kidney stone disease, [1] A kidney stone, 8 millimeters (0.3 in) in diameter: Specialty: Urology, nephrology: Symptoms: Severe pain in the lower back or abdomen, blood in the urine, vomiting, nausea [2] Causes: Genetic and environmental factors [2 ...
A calculus (pl.: calculi), often called a stone, is a concretion of material, usually mineral salts, that forms in an organ or duct of the body. Formation of calculi is known as lithiasis (/ ˌ l ɪ ˈ θ aɪ ə s ɪ s /). Stones can cause a number of medical conditions.
A favorable outcome is more likely if a kidney transplant is complemented by a liver transplant, given the disease originates in the liver. [ citation needed ] Secondary hyperoxaluria is much more common than primary hyperoxaluria, and should be treated by limiting dietary oxalate and providing calcium supplementation.
What causes a kidney stone? There are a number of things that form kidney stones. Those with diseases like high blood pressure, diabetes, and obesity have a higher risk of having kidney stones.
AKI - the other main type of kidney disease - can be caused by dehydration, blood loss, urinary tract obstructions such as kidney stones or blood clots, low blood pressure, or heart disease. It ...
Additionally, hypercalciuria can contribute to kidney stone formation which may present with flank or back pain that comes and goes. It can be painful to pass kidney stones and in extreme cases cause kidney damage. [2] [3] Patients that both form kidney stones and have hypercalciuria are at increased risk for bone loss leading to osteoporosis. [4]
Hypercalcemia usually causes symptoms that lead to chronic dehydration, such as nausea, vomiting, anorexia, and nephrogenic diabetes insipidus (inability of the kidney to concentrate the urine). IV fluid rehydration allows the kidneys to excrete more calcium, and usually lowers the calcium level by 1–2 mg/dL.
Topiramate selectively inhibits cytosolic (type II) and membrane-associated (type IV) forms of carbonic anhydrase. Its action on carbonic anhydrase isoenzymes may contribute to the drug's side effects, including its propensity to cause metabolic acidosis and calcium phosphate kidney stones.
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