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An early life stage (ELS) test is a chronic toxicity test using sensitive early life stages like embryos or larvae to predict the effects of toxicants on organisms. [1] ELS tests were developed to be quicker and more cost-efficient than full life-cycle tests, taking on average 1–5 months to complete compared to 6–12 months for a life-cycle test.
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology.
It was validated both at the hospital and the community level against the standard Denver Developmental Screening Test. [2]With a sensitivity of 66.7% and specificity of 78.8%, it can be used even by community level health worker for mass screening and takes around 5 minutes to complete. [2]
The Gesell Developmental Schedules are a set of developmental metrics which outline the ages & stages of development in young children developed by Dr. Arnold Gesell and colleagues. [1] The original scale is generally considered not to satisfy the standards of rigor currently accepted in the field of psychometrics and is no longer used as an ...
U.S. Army Public Health Center Toxicology Lab technician assessing samples. Toxicology testing, also known as safety assessment, or toxicity testing, is the process of determining the degree to which a substance of interest negatively impacts the normal biological functions of an organism, given a certain exposure duration, route of exposure, and substance concentration.
By comparing a child’s development to the developmental age ranges in this tool, it allows providers to identify young children with developmental problems so that they can be referred for help. The tests address four domains of child development : personal-social (for example, waves bye-bye), fine motor and adaptive (puts block in cup ...
Reproductive toxicity refers to the potential risk from a given chemical, physical or biologic agent to adversely affect both male and female fertility as well as offspring development. [1] Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring.