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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
Mosaic loss of chromosome Y (mLOY) also known as loss of chromosome Y (LOY) occurs to many men in some cells due to aging. Instead of the expected 46,XY karyotype , the affected cells have a 45,X karyotype due to the loss of the Y chromosome .
Pathophysiology of obesity is the study of disordered physiological processes that cause, result from, or are otherwise associated with obesity. A number of possible pathophysiological mechanisms have been identified which may contribute in the development and maintenance of obesity.
48,XXYY syndrome is a condition related to the X and Y chromosomes (the sex chromosomes). People normally have 46 chromosomes in each cell.Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics.
Climbing obesity rates around the world aren't a concern; they've now become a full-fledged problem. Source: Centers for Disease Control & Prevention. In the "Global Burden of Disease" report from ...
Offspring have two sex chromosomes: an offspring with two X chromosomes (XX) will develop female characteristics, and an offspring with an X and a Y chromosome (XY) will develop male characteristics, except in various exceptions such as individuals with Swyer syndrome, that have XY chromosomes and a female phenotype, and de la Chapelle Syndrome ...
Some 38% of men and 40% of women in the study had a BMI of 30 or more by WHO’s standards. When body fat percentage was factored in, this jumped to 71% of men and 64% of women.