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Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects. [1] [2]Relative to their phytoestrogen counterparts, phytoprogestogens are rare. [1]
Laboratory studies have suggested that bioidentical progesterone binds primarily to progesterone receptors, while synthetic progestins activate other receptors with a variety of effects. The editors suggested that progesterone may have neutral to positive effects on the cardiovascular system, and induce apoptosis in breast epithelial cells.
The hormone progesterone is low, and estrogen is building up, she adds. After ovulation, the second half of the cycle, or the luteal phase begins. Progesterone and estrogen increase and the lining ...
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[1] [2] It is a potent agonist of the progesterone receptor (EC 50 = 90 nM). [1] Another compound in the plant, riligustilide , is also a phytoprogestogen, but is almost 1,000-fold less potent and is very weak in comparison (EC 50 ≈ 81 μM).
Diosgenin is a chemical precursor for several hormones, starting with the Marker degradation process, which includes synthesis of progesterone. [4] The process was used in the early manufacturing of combined oral contraceptive pills. [5]
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