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Dimethylformamide, DMF is an organic compound with the chemical formula H C O N(CH 3) 2. Its structure is HC(=O)−N( −CH 3 ) 2 . Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran , or dimethyl fumarate ), this colourless liquid is miscible with water and the majority of organic liquids.
Localized molecular orbitals (LMO) [4] are obtained by unitary transformation upon a set of canonical molecular orbitals (CMO). The transformation usually involves the optimization (either minimization or maximization) of the expectation value of a specific operator.
N,N-dimethylformamide + H 2 O dimethylamine + formate Thus, the two substrates of this enzyme are N,N-dimethylformamide and H 2 O , whereas its two products are dimethylamine and formate . This enzyme belongs to the family of hydrolases , those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides.
It is generated by protonation of (CH 3) 3 COCH(N(CH 3) 2) 2 (Bredereck's reagent). [3](CH 3) 3 COCH(N(CH 3) 2) 2 + H + → (CH 3) 3 COH + [CH(N(CH 3) 2) 2] +. N,N,N′,N′-Tetramethylformamidinium chloride is also obtained in high yield (95%) in the reaction of dimethylformamide (DMF) with dimethylcarbamoyl chloride [4] The conversion of DMF with thionyl chloride in a ratio of 3:1 obtains ...
Dimethylformamide acetal reacts with primary amines to give amidines: [4] Me 2 NC(H)(OMe) 2 + RNH 2 → Me 2 NC=NHR + 2 MeOH. Catalysis is likewise not required for direct amination of an imidoyl chloride. [5] Amidines are also prepared by the addition of organolithium reagents to diimines, followed by protonation or alkylation.
Delocalization of negative charge in a generic carboxylate anion, derived from an organic carboxylic acid (cf. acetic acid), and the corresponding vinylogous carboxylate anion (the "vinylog/vinylogue" of the carboxylate anion), where a vinyl group now separates the charged oxygen from the carbonyl (C=O) group.
Formyl functional group is shown in blue. Formylation refers to any chemical processes in which a compound is functionalized with a formyl group (-CH=O). In organic chemistry, the term is most commonly used with regards to aromatic compounds (for example the conversion of benzene to benzaldehyde in the Gattermann–Koch reaction).
When reacted with carbon nucleophiles, N,N-dimethylformamide (DMF) can be used to introduce a formyl group. [10] Because tertiary amides only react once with organolithiums, they can be used to introduce aldehyde and ketone functionalities. Here, DMF serves as a source of the formyl group in the synthesis of benzaldehyde.