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Arthrobacter, like other bacterial genera including Brevibacterium, Microbacterium, and Corynebacterium are used for industrial production of L-glutamate. In industrial applications, Arthrobacter is often grown with low-cost sugar sources such as cane or beet molasses, starch hydrolysates from corn or cassava tubers, or tapioca.
Actinomycetota-derived antibiotics that are important in medicine include aminoglycosides, anthracyclines, chloramphenicol, macrolide, tetracyclines, etc. [citation needed] Actinomycetota have high guanine and cytosine content in their DNA. [21] The G+C content of Actinomycetota can be as high as 70%, though some may have a low G+C content. [22]
Novobiocin, also known as albamycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides [1] a member of the class Actinomycetia. Other aminocoumarin antibiotics include clorobiocin and coumermycin A1. [2]
Actinomycetales can be found mostly in soil and decaying organic matter, as well as in living organisms such as humans and animals. They form symbiotic nitrogen fixing associations with over 200 species of plants, and can also serve as growth promoting or biocontrol agents, or cause disease in some species of plants.
Bacitracin is a polypeptide antibiotic derived from a bacterium, Bacillus subtilis, and acts against bacteria through the inhibition of cell wall synthesis. [6] It does this by inhibiting the removal of phosphate from lipid compounds, thus deactivating its function to transport peptidoglycan; the main component of bacterial cell membranes, to the microbial cell wall.
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Sequence alignments of actinomycetotal genomes have led to the identification of three conserved signature indels which are unique to the order Streptomycetales. The enzyme PBGD contains a four-amino-acid insertion which is present in all Streptomyces species and Kitasatospora setae, but not any other Actinomycetota.
The increased cell length can protect bacteria from protozoan predation and neutrophil phagocytosis by making ingestion of cells more difficult. [1] [3] [4] [5] Filamentation is also thought to protect bacteria from antibiotics, and is associated with other aspects of bacterial virulence such as biofilm formation. [6] [7]