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4-Phenylpiperidine is a chemical compound. It features a benzene ring bound to a piperidine ring. 4-Phenylpiperidine is the base structure for a variety of opioids , such as pethidine (meperidine), ketobemidone , alvimopan , loperamide , and diphenoxylate .
Chemical structure of 4-phenylpiperidine. Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine . Of particular interest are a variety of derivatives of 4-phenylpiperidine , which have pharmacological effects including morphine -like activity [ 1 ] or other central nervous system effects.
Pyridine and poly(4-vinyl) pyridine have been shown to form conducting molecular wires with remarkable polyenimine structure on UV irradiation, a process which accounts for at least some of the visible light absorption by aged pyridine samples. These wires have been theoretically predicted to be both highly efficient electron donors and ...
4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors. [ 1 ] 4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia -evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection ; this involves the prevention of ischemia-induced intracellular Ca 2+ dysregulation.
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine . It is of interest as a precursor to the monoaminergic neurotoxin MPP + , which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain .
Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: [12] C 5 H 5 N + 3 H 2 → C 5 H 10 NH. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. [13]
Muscle Loss. IF YOU DROP 15 to 25 percent of your body weight, 15 to 60 percent of that could be lean mass (muscle, bone, anything but fat). Strength training helps counter that. In one study of ...
Acetoacetate can be used instead of diethyl-α-ketoglurate in the presence of indium salts. [4] The use of aniline has also been reported in the original Publication. [2] The product of this reaction shows transoid configuration of the phenyl groups at C-2 and C-6. Indium mediated variant