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Cannabis was used in Africa to restore appetite and relieve pain of hemorrhoids. It was also used as an antiseptic. In a number of countries, it was used to treat tetanus, hydrophobia, delirium tremens, infantile convulsions, neuralgia and other nervous disorders, cholera, menorrhagia, rheumatism, hay fever, asthma, skin diseases, and ...
7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. [1] While methods have been developed for its synthetic production, [2] and measurement of levels in the body following consumption of cannabidiol, [3] its pharmacology has been relatively little studied, though it has been found to possess similar ...
Hemorrhoids (or haemorrhoids), also known as piles, are vascular structures in the anal canal. [ 7 ] [ 8 ] In their normal state, they are cushions that help with stool control. [ 2 ] They become a disease when swollen or inflamed ; the unqualified term hemorrhoid is often used to refer to the disease. [ 8 ]
Recovery from the surgical removal of hemorrhoids (a.k.a. hemorrhoidectomy) can be extremely painful, notes Dr. Bernstein, but it’s one of the most effective ways to get rid of hemorrhoids for good.
The ancient Egyptians used hemp (cannabis) in suppositories for relieving the pain of hemorrhoids. [11] Around 2,000 BCE, the ancient Egyptians used cannabis to treat sore eyes. [12] The egyptologist Lise Manniche notes the reference to "plant medical cannabis" in several Egyptian texts, one of which dates back to the eighteenth century BCE. [13]
Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. [17] Medically, it is an anticonvulsant used to treat multiple forms of epilepsy. [4]
CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [69] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [57] The terminal half-life is approximately 18–32 hours. [70]
Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive or sedative effects.