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Peptide amphiphiles were developed in the 1990s. They were first described by the group of Matthew Tirrell in 1995. [5] [6] These first reported PA molecules were composed of two domains: one of lipophilic character and another of hydrophilic properties, which allowed self-assembly into sphere-like supramolecular structures as a result of the association of the lipophilic domains away from the ...
A notable system in this category is a nanotubular supramolecular polymer formed by the supramolecular polymerization of amphiphilic hexa-peri-hexabenzocoronene (HBC) derivatives. [26] Generally, nanotubes are categorized as 1D objects morphologically, however, their walls adopt a 2D geometry and therefore require a different design strategy ...
The phospholipid amphiphiles are the major structural component of cell membranes. Amphiphiles are the basis for a number of areas of research in chemistry and biochemistry, notably that of lipid polymorphism. Organic compounds containing hydrophilic groups at both ends of the molecule are called bolaamphiphilic.
This drug, like many others, normally requires large dosages to reach the target brain tissue diffusion from the blood, leading to systemic toxicity and the possibilities of multiple harmful side effects manifesting throughout the body. However, focused ultrasound has the potential to increase the safety and efficacy of drug delivery to the brain.
Thin-film drug delivery uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually) and/or via the small intestines (enterically). A film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via ...
Transfersome is a proprietary drug delivery technology, an artificial vesicle designed to exhibit the characteristics of a cell vesicle suitable for controlled and potentially targeted drug delivery. Some evidence has shown efficacy for its use for drug delivery without causing skin irritation, [1] potentially being used to treat skin cancer. [2]
A lunar eclipse above Lofer, Austrian province of Salzburg, in the early hours of Monday, Sept. 28, 2015. (AP Photo/Kerstin Joensson)
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...