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Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed to its action on AMPK, although other mechanisms have been proposed. [215] [216] Metformin has been studied for its effects on multiple other conditions, including:
Metformin is the main drug used for treatment, as it is normally used for patients with hyperglycemia. [15] Metformin reduces appetite and improves symptoms of hepatic steatosis and polycystic ovary syndrome. [4] Leptin can also be used to reverse insulin resistance and hepatic steatosis, to cause reduced food intake, and decrease blood glucose ...
Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue. [ 1 ] [ 2 ] The medical condition is characterized by abnormal or degenerative conditions of the body's adipose tissue .
Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. [3] It may be used with metformin, a sulfonylurea, or insulin. [3] [4] Use is recommended together with exercise and diet. [4] It is not recommended in type 1 diabetes. [4] It is taken by mouth. [4]
Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. [7] In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. [8]
Timing is everything for many things in life — including when to take medication like metformin, sold under the brand names Glucophage, Fortamet, Riomet, and Glumetza.
Exenatide, sold under the brand name Byetta among others, is a medication used to treat type 2 diabetes. [7] It is used together with diet, exercise, and potentially other antidiabetic medication. [7] It is a treatment option after metformin and sulfonylureas. [8] It is given by injection under the skin. [7]
Because many drugs are excreted in human milk, pioglitazone/metformin should not be administered to a breastfeeding woman. [medical citation needed] Precautions. Pioglitazone/metformin should not be used in people with type 1 diabetes or for the treatment of diabetic ketoacidosis and should be used with caution in people with edema. Serum ALT ...
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