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Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules.
A platelet count (PLT) is a test that measures the number of platelets in your blood. Platelets help your blood clot. Too few platelets can be a sign of cancer, infections or other health problems.
Tests measure average platelet levels per microliter (mcL) of blood. Below are guideline platelet levels. What does it mean when your platelet count is low? A low platelet count can make it...
Platelet Factor 4 is a small chemokine sequestered in platelets, rapidly secreted upon activation, and known for neutralizing the effects of heparin on endothelial cells to promote coagulation. Additionally, it inhibits endothelial cell migration, proliferation, and angiogenesis both in vitro and in vivo.
This topic summarizes available platelet function tests and provides information about how to interpret the results of platelet function testing. Separate topics discuss a general approach to evaluating unexplained bleeding and the evaluation and management of specific platelet function disorders:
Platelets, which work best at higher shear rates, help to form a physical barrier against further blood loss and, at the same time, provide a surface on which thrombin is generated and fibrin can accumulate.
A platelet count measures the number of platelets in your blood. Learn about the test, its results, conditions like thrombocytopenia and thrombocytosis, and prep tips.
Platelet transfusion experiments indicate that circulating platelet half-life is independent of platelet PF4 level, suggesting that the inverse relationship between platelet count and endogenous PF4 levels is due to an in vivo platelet production defect.
Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated platelets, may cause a number of pathophysiological conditions. The most commonly known is heparin-induced thrombocytopenia (HIT), which develops in a small proportion of people treated with the anticoagulant drug heparin.
There are two types of platelet tests: a platelet count test and platelet function tests. A platelet count test measures the number of platelets in your blood. A lower than normal platelet count is called thrombocytopenia. This condition can cause you to bleed too much after a cut or other injury that causes bleeding.