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Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [1]It was patented in 1986 and approved for medical use in 1996. [4]
The medication has been found to achieve 96.7% to 97.3% inhibition of aromatase at a dosage of 1 mg/day and 98.1% inhibition of aromatase at a dosage of 10 mg/day in humans. [ 4 ] [ 3 ] As such, 1 mg/day is considered to be the minimal dosage required to achieve maximal suppression of aromatase with anastrozole. [ 4 ]
[1] [14] [15] [16] The medication is used at a lower dosage of 150 mg once per day or at a higher dosage of 200 mg twice per day, depending on the severity of symptoms. [ 1 ] [ 14 ] The effectiveness of elagolix in the treatment of symptoms of endometriosis was demonstrated in the 6-month Elaris Endometriosis I and II (EM-I and EM-II) phase III ...
[13] [9] Peak levels of tamoxifen after a single 40 mg oral dose were 65 ng/mL and steady state levels at 20 mg/day were 310 ng/mL. [7] Levels of tamoxifen show clear dose dependency across a dosage range of 1 to 20 mg/day. [7] [95] Endoxifen levels are approximately 5 to 10 times higher than afimoxifene levels, with large interindividual ...
2005 (January): The product insert added a warning in bold-face type: "Do not use in cats." [56] 2005: The FDA sent a Notice of Violation to the manufacturer for its promotional materials which included promotion of the drug for off-label use. [57] 2020 (February): A meloxicam injection was approved for use in the United States.
On January 31, 2017, Amnesty International published a report of their investigation of 59 drug-related killings in 20 cities and towns, "'If you are poor you are killed': Extrajudicial Executions in the Philippines' 'War on Drugs'", which "details how the police have systematically targeted mostly poor and defenceless people across the country ...
January 10–15 – A national plebiscite referendum is held among the citizens' assemblies to ratify the new Constitution. [1] [2]January 15 – Chinese Lim Seng (Guan Suo So), upon order from Pres. Marcos on January 3, is publicly executed by firing squad in a firing range in Fort Bonifacio, Rizal for drug trafficking; the country's first execution by that method after 27 years, and only ...
On October 28, 1931, the Act No. 3827 was approved declaring the last Sunday of August as National Heroes Day. [6] As per Republic Act No. 3022, [7] April 9th was proclaimed as Bataan Day. Independence Day was changed from July 4 (Philippine Republic Day) to June 12 (Philippine Independence Day) on August 4, 1964. [8] January 1 – New Year's Day