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For treating gout, the initial effects of colchicine occur in a window of 12 to 24 hours, with a peak within 48 to 72 hours. [26] It has a narrow therapeutic window, requiring monitoring of the subject for potential toxicity. [26] Colchicine is not a general pain-relief drug, and is not used to treat pain in other disorders. [26]
Name Other common names Scientific name Drug Adverse effects Cinchona bark Cinchona pubescens: Warfarin Possible additive effect [3] Chamomile: Blood thinners [23] Devil's Claw: grapple plant, wood spider Harpagophytum: Warfarin Additive effect [3] Ephedra Ephedra: Caffeine, decongestants, stimulants [15] Increases sympathomimetic effect of ...
Warfarin, sold under the brand name Coumadin among others, is an anticoagulant medication. [12] While the drug is described as a "blood thinner", it does not reduce viscosity but rather prevents blood clots ( thrombus ) from forming ( coagulating ).
In 1884 John Berry Haycraft described a substance found in the saliva of leeches, Hirudo medicinalis, that had anticoagulant effects. He named the substance ‘Hirudine’ from the Latin name. The use of medicinal leeches can be dated back all the way to ancient Egypt. [2]
Commonly prescribed drugs are prescribed according to guidelines around the world. For instance, for ischemic heart disease, the American College of Cardiology/American Heart Association (ACC/AHA) guideline is used in the United States and the European Society of Cardiology (ESC) guideline is used in Europe.
The rodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins ("Coumadin" is a brand name for warfarin). They are also referred to as "coumarins," in reference to their derivation, although this term also may be deceptive since coumarin itself, as noted, is not active in clotting, and is used ...
Some clopidogrel users have defective CYP2C19 activity and therefore poor CYP2C19 metabolism that leads to the risk of reduced activity of clopidogrel. This is because the prodrug does not metabolized to the active drug. Drugs that are CYP2C19 inhibitors can interact with clopidogrel and reduce clopidogrel activity.
While colchicine is not used to treat cancer in humans, it is commonly used to treat acute attacks of gout. [26] Colchicine is an anti-inflammatory drug that has been in continuous use for more than 3000 years. Colchicine is an oral drug, known to be used for treating acute gout and preventing acute attacks of familial Mediterranean fever (FMF).
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