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Ribosome profiling, or Ribo-Seq (also named ribosome footprinting), is an adaptation of a technique developed by Joan Steitz and Marilyn Kozak almost 50 years ago that Nicholas Ingolia and Jonathan Weissman adapted to work with next generation sequencing that uses specialized messenger RNA sequencing to determine which mRNAs are being actively translated.
Ribosome profiling provides valuable insights into translation dynamics, revealing the complex interplay between gene sequence, mRNA structure, and translation regulation. For example, research utilizing this method has revealed that genetic differences and their subsequent expression as mRNAs can also impact translation rate in an RNA-specific ...
This method enables researchers to take a snapshot of the translatome, showing which parts of the mRNA are being translated into proteins by ribosomes at a given time. Ribosome profiling provides valuable insights into translation dynamics, revealing the complex interplay between gene sequence, mRNA structure, and translation regulation.
This may cause a problem with ribosome profiling because the methods that are used to stop translation in an experiment can impact the outcome, which causes incorrect results. Ribosome profiling is useful for getting specific information on translation and the process of protein synthesis. [20]
Other methods are polysome profiling, full-length translating mRNA profiling , and translating ribosome affinity purification (TRAP-seq). [4] Unlike the transcriptome , the translatome is a more accurate approximation for estimating the expression level of some genes , since the correlation between the proteome and translatome is higher than ...
In particular, polysome profiling [2] [3] and ribosome (translation) profiling [4] approaches are also employed to identify mRNA involved in polysome formation and locations of elongating ribosomes over coding regions of transcripts, correspondingly. These methods, however, do not use chemical stabilisation of translation complexes and ...
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Ribosome profiling has been used to identify potential micropeptides in a growing number of organisms, including fruit flies, zebrafish, mice and humans. [11] One method uses compounds such as harringtonine, puromycin or lactimidomycin to stop ribosomes at translation initiation sites. [12] This indicates where active translation is taking place.
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