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Dose de-escalation below the starting doses in case of poor patient's chemotherapy tolerability applies to cyclophosphamide only. If the nadir ANC > 500/μL, then the doses of etoposide, doxorubicin, and cyclophosphamide for the next cycle are all increased by 20% over the doses used in the previous cycle.
This distinction must be made by both the treating physicians and the cancer patients themselves. Many oncologists in their daily clinical practice follow their patients' malignant disease by means of repeated imaging studies and make decisions about continuing therapy on the basis of both objective and symptomatic criteria.
The consequences of overdiagnosis and overtreatment resulting from cancer screening can lead to a decline in quality of life, due to the adverse effects of unnecessary medication and hospitalization. [10] [12] [13] The accuracy of a cancer screening test relies on its sensitivity, and low sensitivity screening tests can overlook cancers. [10]
Having a super-sensitive multi-cancer screening tool that could actually save lives is the “holy grail” for cancer researchers and physicians. The aptly named health care company Grail claims ...
The best studies for assessing whether a screening test will increase a population's health are rigorous randomized controlled trials.When studying a screening program using case-control or, more usually, cohort studies, various factors can cause the screening test to appear more successful than it really is. A number of different biases ...
"ACS develops guidelines for cancer screening and prevention, informed by the latest available data and evidence, to meet the needs of clinicians, the general public, and policy," he said.
A tumor marker is a biomarker that can be used to indicate the presence of cancer or the behavior of cancers (measure progression or response to therapy). They can be found in bodily fluids or tissue. Markers can help with assessing prognosis, surveilling patients after surgical removal of tumors, and even predicting drug-response and monitor ...
Urine drug tests screen the urine for the presence of a parent drug or its metabolites. The level of drug or its metabolites is not predictive of when the drug was taken or how much the patient used. [19] Urine drug testing is an immunoassay based on the principle of competitive binding. Drugs which may be present in the urine specimen compete ...