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It is characterized by dull-red papules that progress to well-circumscribed, small, round, atrophic hyperpigmented skin lesions usually on the shins. It is the most common [1]: 540 [2]: 681 of several diabetic skin conditions, being found in up to 30% of diabetics. Similar lesions can occasionally be found in non-diabetics usually following ...
Conditions included in this group are: [1] [2] Acral dry gangrene; Carotenosis; Diabetic dermopathy; Diabetic bulla; Diabetic cheiroarthropathy; Malum perforans; Necrobiosis lipoidica; Limited joint mobility is observed in roughly 30% of people with diabetes with longstanding disease. [1] Scleredema; Waxy skin is observed in roughly 50%. [1]
Skin conditions resulting from errors in metabolism are caused by enzymatic defects that lead to an accumulation or deficiency of various cellular components, including, but not limited to—amino acids, carbohydrates, and lipids
Schamberg's disease is a skin disorder that causes a discoloration of the lower extremities. [4] It usually occurs in the lower extremities and rarely elsewhere. [4] This condition is caused by leaky blood vessels near the surface of the skin. [7] The cause of the leaky capillaries is usually not known. [7]
Inherited metabolic disorders are one cause of metabolic disorders, and occur when a defective gene causes an enzyme deficiency. [6] These diseases, of which there are many subtypes, are known as inborn errors of metabolism. [7] Metabolic diseases can also occur when the liver or pancreas do not function properly. [3]
Diabetic cheiroarthropathy, also known as diabetic stiff hand syndrome or limited joint mobility syndrome, is a cutaneous condition characterized by waxy, thickened skin and limited joint mobility of the hands and fingers, leading to flexion contractures, a condition associated with diabetes mellitus [1]: 681 and it is observed in roughly 30% of diabetic patients with longstanding disease.
They usually occur just under the skin, but occasionally may be deeper. [1] Most are less than 5 cm (2.0 in) in size. [2] Common locations include upper back, shoulders, and abdomen. [4] It is possible to have several lipomas. [3] The cause is generally unclear. [1] Risk factors include family history, obesity, and lack of exercise.
Complications are either directly caused by obesity or indirectly related through mechanisms sharing a common cause such as a poor diet or a sedentary lifestyle. The strength of the link between obesity and specific conditions varies. One of the strongest is the link with type 2 diabetes. Excess body fat underlies 64% of cases of diabetes in ...