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Familial Alzheimer's disease mutations commonly used in animal models. Rodent animal models of Alzheimer's disease are commonly used in research as rodents and humans have many of the same major brain regions and neurotransmitter systems. [5] These models are small, easy to house, as well as breed very well. [26]
However, because the only difference between the family members who developed Alzheimer's disease and those that did not in these families was the inheritance of the mutation in the amyloid gene, this suggested that the amyloid protein itself could cause the disease. The idea that amyloid could cause the disease influenced scientific research ...
It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations.
Alzheimer’s usually is a disease of people over age 65 and while simply getting older is the main risk, the APOE gene has long been known to play some role. It comes in three main varieties.
Alzheimer's disease does not affect all memory capacities equally. Older memories of the person's life (episodic memory), facts learned (semantic memory), and implicit memory (the memory of the body on how to do things, such as using a fork to eat or how to drink from a glass) are affected to a lesser degree than new facts or memories. [42] [43]
In the English language, many animals have different names depending on whether they are male, female, young, domesticated, or in groups. The best-known source of many English words used for collective groupings of animals is The Book of Saint Albans , an essay on hunting published in 1486 and attributed to Juliana Berners . [ 1 ]
Alzheimer's disease (AD) is a complex neurodegenerative disease that affects millions of people across the globe. [1] It is also a topic of interest in the East Asian population, especially as the burden of disease increases due to aging and population growth. [2] The pathogenesis of AD between ethnic groups is different. [3]
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