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A lethal infection in mink, the Aleutian disease virus lies dormant in ferrets until stress or injury allows it to surface. While the parvovirus itself causes little or no harm to the ferret host, the large number of antibodies produced in response to the presence of the virus results in a systemic vasculitis, resulting in eventual renal failure, bone marrow suppression and death. [10]
The virus replicates in the cells of the crypt epithelium in the duodenum and jejunum and, to a lesser extent the ileum, colon and caecum. The severity of the disease is directly related to necrosis of the crypt epithelium. [2] Virus enteritis of mink was recognized first in 1947 when epizootics occurred among ranch mink in southern Canada.
The first known transmission of SARS-CoV-2 among wild mink was reported in Utah, which researchers believed was due to contact with infected captive mink rather than through an intermediary vector in the wild or direct human-to-mink transmission. [1]
The NS gene encodes the non-structural (NS) protein NS1, which is the replication initiator protein, and the VP gene encodes the viral protein (VP) that the viral capsid is made of. NS1 contains an HUH superfamily endonuclease domain near its N-terminus , containing both site-specific binding activity and site-specific nicking activity, and a ...
The sylvatic cycle, also enzootic or sylvatic transmission cycle, is a portion of the natural transmission cycle of a pathogen. Sylvatic refers to the occurrence of a subject in or affecting wild animals. The sylvatic cycle is the fraction of the pathogen population's lifespan spent cycling between wild animals and vectors. Humans are usually ...
To enter the cells, proteins on the surface of the virus interact with proteins of the cell. Attachment, or adsorption, occurs between the viral particle and the host cell membrane. A hole forms in the cell membrane, then the virus particle or its genetic contents are released into the host cell, where replication of the viral genome may commence.
Carnivore protoparvovirus 1 is a species of parvovirus that infects carnivorans.It causes a highly contagious disease in both dogs and cats separately. The disease is generally divided into two major genogroups: FPV containing the classical feline panleukopenia virus (FPLV), and CPV-2 containing the canine parvovirus type 2 (CPV-2) which appeared in the 1970s.
[3] Although the mechanism of replication has not been studied heavily, anelloviridae appears to use the rolling circle mechanism where first ssDNA is converted to dsDNA. It requires a host polymerase for replication to occur as the genome itself does not encode for a viral polymerase and, as a result, anelloviridae must replicate inside the ...