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Process Biochemistry is a monthly peer-reviewed scientific journal that covers the study of biochemical processes and their applications in industries, such as food, pharmaceuticals, and biotechnology. The journal was established in 1966 and is published by Elsevier. The editor-in-chief is Joseph Boudrant (University of Lorraine).
One of the most prominent uses of biocatalysis in process chemistry today is in the synthesis of Januvia®, a DPP-4 inhibitor developed by Merck for the management of type II diabetes. The traditional process synthetic route involved a late-stage enamine formation followed by rhodium-catalyzed asymmetric hydrogenation to afford the API ...
Bioreactor. Biochemical engineering, also known as bioprocess engineering, is a field of study with roots stemming from chemical engineering and biological engineering.It mainly deals with the design, construction, and advancement of unit processes that involve biological organisms (such as fermentation) or organic molecules (often enzymes) and has various applications in areas of interest ...
Genetic engineering – taking a gene from one organism and placing it into another. Biochemists inserted the gene for human insulin into bacteria. The bacteria, through the process of translation, create human insulin. Cloning – Dolly the sheep was the first mammal ever cloned from adult animal cells. The cloned sheep was, of course ...
The entire process converts two amino groups, one from NH + 4 and one from aspartate, and a carbon atom from HCO − 3, to the relatively nontoxic excretion product urea. [6] This occurs at the cost of four "high-energy" phosphate bonds (3 ATP hydrolyzed to 2 ADP and one AMP). The conversion from ammonia to urea happens in five main steps.
In molecular biology and biochemistry, processivity is an enzyme's ability to catalyze "consecutive reactions without releasing its substrate". [1]For example, processivity is the average number of nucleotides added by a polymerase enzyme, such as DNA polymerase, per association event with the template strand.
Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. [1] A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at ...
The process begins with the synthesis of a very large oligonucleotide library, consisting of randomly generated sequences of fixed length flanked by constant 5' and 3' ends. The constant ends serve as primers , while a small number of random regions are expected to bind specifically to the chosen target.
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