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For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6. This is a slight change from the pre-2005 Gleason system where the second number was the secondary grade (i.e., the grade of the second-most common cell line pattern). [4]
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Of the many cancer-specific schemes, the Gleason system, [3] named after Donald Floyd Gleason, used to grade the adenocarcinoma cells in prostate cancer is the most famous. This system uses a grading score ranging from 2 to 10. Lower Gleason scores describe well-differentiated less aggressive tumors.
Below is the grading system found to be most commonly used in United States public high schools, according to the 2009 High School Transcript Study. [2] This is the most used grading system; however, there are some schools that use an edited version of the college system, which means 89.5 or above becomes an A average, 79.5 becomes a B, and so on.
In contrast to the original Gleason grading system, it is now recommended that on a needle core biopsy both the most common and highest grade are added together for the Gleason score [2]. For example, if there is 60 % Gleason pattern 3, 35 % Gleason pattern 4, and 5 % Gleason pattern 5, the Gleason score would be 3 + 5 = 8.
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In the Czech Republic, primary and secondary schools use a 5-point grade system, with 1 as the best and 5 as the worst. They correspond to the following ratings: 1 = výborně (excellent), 2 = chvalitebně (commendable), 3 = dobře (good), 4 = dostatečně (sufficient), and 5 = nedostatečně (insufficient).