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Both of them are considered as first-line anti-anxiety medications. TCAs are second-line treatment as they cause more significant adverse effects when compared to the first-line treatment. Benzodiazepines are effective in emergent and short-term treatment of anxiety disorders due to their fast onset but carry the risk of dependence. [4]
Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968. [3] Clobazam was first synthesized in 1966 and first published in 1969. Clobazam was originally marketed as an anxioselective anxiolytic since 1970, [4][5] and an anticonvulsant since 1984. [6]
Flurazepam. Flurazepam[2] (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite with a long half-life, which may stay in the bloodstream for days. [3]
The unchanged drug was 96% bound to plasma proteins. The blood-level decline of the parent drug was biphasic, with the short half-life ranging from 0.4 to 0.6 hours and the terminal half-life from 3.5 to 18.4 hours (mean 8.8 hours), depending on the study population and method of determination. [62]
Nitrazepam, sold under the brand name Mogadon among others, [2] [3] is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. [4] It also has sedative (calming) properties, [ 5 ] as well as amnestic (inducing forgetfulness), anticonvulsant , and skeletal muscle relaxant effects.
As brand name Librium and a generic, chlordiazepoxide is typically used to treat anxiety and certain symptoms of alcohol/drug withdrawal. Clonazepam. Better known as Klonopin, this medication is ...
Used to treat anxiety in the short-term, benzodiazepines provide relief from anxiety symptoms in as little as 30 minutes to one hour. They promote a relaxed feeling, which is why Xanax is often ...
Prazepam is indicated for the short-term treatment of anxiety. After short-term therapy, the dose is usually gradually tapered-off to reduce or avoid any withdrawal or rebound effects . [ 5 ] [ 6 ] Desmethyldiazepam , an active metabolite , has a very long half-life of 29 to 224 hours, which contributes to the therapeutic effects of prazepam.
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