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Genetic theories of aging propose that aging is programmed within each individual's genes. According to this theory, genes dictate cellular longevity. Programmed cell death, or apoptosis, is determined by a "biological clock" via genetic information in the nucleus of the cell. Genes responsible for apoptosis provide an explanation for cell ...
Circadian clock, a molecular mechanism that results in a circadian rhythm in a living organism; Circadian rhythm, biological process that displays an oscillation about 24 hours, such as the human sleep-wake cycle (the "body clock") Epigenetic clock, a set of DNA sites whose methylation levels can be used to measure aging throughout the body
An epigenetic clock is a biochemical test that can be used to measure age. The test is based on modifications that change over time and regulate how genes are expressed. Typically, the test examines DNA methylation levels, measuring the accumulation of methyl groups to one's DNA molecules, or more recently, based on the histone
The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 [1] to conceptualize the essence of biological aging and its underlying ...
Until recently, epigenetic clocks have primarily been used in the lab, but a few are now available to consumers. Some have price tags upwards of $500. ... Understanding biological aging can be ...
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.
Download as PDF; Printable version; ... Pages in category "Theories of biological ageing" ... Aging by design theory; Aging theories based on evolvability;
Theoretically, it is possible upon the discovery of the exact mechanism of biological immortality to genetically engineer cells with the same capability. The length of the telomere strand has senescent effects; telomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins such as progerin , which ...