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Imaging lenses and digital cameras (CCD or CMOS) are used to produce the final image. Live video processing can also be performed to enhance contrast during fluorescence detection and improve signal-to-background ratio. In recent years a number of commercial companies have emerged to offer devices specializing in fluorescence in the NIR ...
Radiation therapy is commonly used in prostate cancer treatment. It may be used instead of surgery or after surgery in early-stage prostate cancer (adjuvant radiotherapy). Radiation treatments also can be combined with hormonal therapy for intermediate risk disease, when surgery or radiation therapy alone is less likely to cure the cancer.
Fluorescence image guided surgery: is a medical imaging approach that fluorescently labels a mass to aid in navigation. For example, indocyanine green can be used to detect lymph nodes in cancer patients. [4]
Scientists from Purdue University designed and developed OTL38 and licensed it to On Target Laboratories in 2013. [9] [10] The safety and effectiveness of pafolacianine was evaluated in a randomized, multi-center, open-label study of women diagnosed with ovarian cancer or with high clinical suspicion of ovarian cancer who were scheduled to undergo surgery.
Near-infrared fluorescence imaging: Emerging applications in robotic upper urinary tract surgery. Eur Urol. Apr 2014; 65(4):793-801. Borofsky M, Stifelman MD. Near-infrared fluorescence imaging in robotic partial nephrectomy. In Robotic Renal Surgery: Benign and Cancer Surgery for the Kidneys and Ureters (pp. 89-96). Springer US, 2013.
In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. [19] Because of this high expression, PSMA is being developed as potential biomarker for therapy and imaging of some cancers. [20]
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