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The WI-38 cell line stemmed from earlier work by Hayflick growing human cell cultures. [2]In the early 1960s, Hayflick and his colleague Paul Moorhead at the Wistar Institute in Philadelphia, Pennsylvania discovered that when normal human cells were stored in a freezer, the cells remembered the doubling level at which they were stored and, when reconstituted, began to divide from that level to ...
WI-38, or new diploid cell strains, are used today for the manufacture of most human virus vaccines produced throughout the world including those for poliomyelitis, rubella, rubeola, varicella, mumps, rabies, adenoviruses and hepatitis A. Over one billion vaccinees have received vaccines produced on WI-38 or foreign versions of Hayflick's ...
The WI-38 cell strain he developed at the Institute with Paul S. Moorhead, Ph.D., became the substrate for the production of many human virus vaccines. [ 25 ] Helen Dean King , Ph.D.: a biologist and the first woman research professor at Wistar and one of the first in the U.S. [ 26 ] A faculty member from 1909 to 1950, Dr. King researched the ...
[11] [13] [14] Descendants of the fibroblast cells from these fetuses have been growing in labs ever since, as the WI-38 and MRC-5 cell lines. They are still used to grow vaccine viruses today. [15] [1] As of March 2017, billions of vaccines have been given that were made using the WI-38 line alone. [16]
He developed a vaccine for rubella, based upon the RA 27/3 strain of the virus (also developed by Plotkin using WI-38, a fetal-derived human cell line), which was released to the public in 1969. [8] The enabling technology was the WI-38 cell strain gifted to Plotkin by Leonard Hayflick also of the Wistar. WI-38 provide the key elements for the ...
The vaccine was attenuated and prepared in the WI-38 normal human diploid cell strain which was ... The strain became the preferred vaccine used by ...
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Chanock was named head of the NIAID's Laboratory of Infectious Diseases in 1968. The WI-38 normal human cell strain gifted to Chanock resulted in the development of an adenovirus vaccine in 1964. This vaccine has been used in the world's military where the virus produces a disease similar to the flu and forces recruits to enter clinics for many ...