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Although stress isn’t linked to long-term high blood pressure, it can lead to temporary and sometimes dramatic spikes in blood pressure. If these spikes occur, they can damage your heart, blood vessels, and kidneys, similar to how hypertension affects your body. Benzodiazepines are known to have hypotensive effects.
The primary question about the effect of benzodiazepines in lowering BP remains unanswered. In this meta-analysis of seven studies, benzodiazepines were found comparable to standard drugs in reducing systolic and diastolic BP in patients having hypertension.
Long-term use of benzodiazepines by ≥60 years old was independently associated with lower diastolic and systolic blood pressure in all parameters of ABPM, but not among younger patients.
The effect of chronic benzodiazepine use on blood pressure has not been documented. We aimed to evaluate whether regular benzodiazepine use can be associated to the results of ambulatory blood pressure monitoring (ABPM).
Many traditional benzodiazepines are broken down in the liver and when combined with drugs that block this action, blood levels can rise, leading to side effects. Lorazepam, oxazepam and temazepam are less likely to have this risk due to fewer liver enzyme interactions.
Benzodiazepines are CNS depressants specifically inhibiting respiratory drive. Therefore, careful monitoring of all vitals, especially blood pressure and respiratory rate, should be performed after the administration of benzodiazepines. In addition, waveform capnography should be considered to monitor respiratory status.
Keywords: Adverse effects, benzodiazepines, central nervous system. INTRODUCTION. Benzodiazepines ... causes peripheral vasodilation and a subsequent decrease in arterial blood pressure. This effect is more pronounced than that seen with diazepam. Midazolam is primarily metabolized by cytochrome p450 into the inactive metabolite 1 ...
Benzodiazepines target and bind to a receptor in the brain and spinal cord called GABA-A by mimicking naturally occurring GABA. This is what causes the effects of CNS depression, like sleepiness and calmness.
Background: Older people taking benzodiazepines (BDZs) have higher risk of falling, which is mainly attributed to cognitive and psychomotor effects. BDZs may also have hypotensive effects. We investigated the association between BDZs and orthostatic blood pressure behaviour in older people.
However, studies comparing the effect of benzodiazepines in lowering blood pressure (BP) are equivocal. This systematic review and meta-analysis was planned to assess the efficacy of benzodiazepines in reducing blood pressure in short term among hypertensive patients.