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The disease is specific to the Samoyed, in that the Samoyed is the only breed of dog to show the more rapid progression to kidney failure and death, as well as affecting males to a much more severe degree than females. The Samoyed, however, is not the only breed of dog to suffer from life-threatening renal diseases.
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
Stones can form in any part of the urinary tract in dogs and cats, but unlike in humans, stones of the kidney are less common and do not often cause significant disease, although they can contribute to pyelonephritis and chronic kidney disease. Types of stones include struvite, calcium oxalate, urate, cystine, calcium phosphate, and silicate ...
Despite its relative rarity compared to limb prosthesis, strides have been made over the decades, with notable milestones such as the first pacemaker surgery on a dog in 1968 and successful kidney transplants in cats since the mid-1980s. This field faces challenges, particularly in canine programs, due to issues related to immunosuppression.
It can result in chronic kidney failure, hypoalbuminemia, which can cause ascites and peripheral edema, and nephrotic syndrome, which can cause hypertension or hypercoagulability. [156] Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited.
The reason some dogs develop kidney failure following ingestion of grapes and raisins is not known. [3] Types of grapes involved include both seedless and seeded, store-bought and homegrown, and grape pressings from wineries. [4] A mycotoxin is suspected to be involved, but none has been found in grapes or raisins ingested by affected dogs. [5]
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