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Diagnosis of NBCCS is made by having two major criteria or one major and two minor criteria. [12] The major criteria consist of the following: more than 2 BCCs or 1 BCC in a person younger than 20 years; odontogenic keratocysts of the jaw; 3 or more palmar or plantar pits; ectopic calcification or early (<20 years) calcification of the falx cerebri
Preauricular sinuses and preauricular cysts are two common congenital malformations. Each involves the external ear. The difference between them is that a cyst does not connect with the skin, but a sinus does. [3] Frequency of preauricular sinus differs depending the population: 0.1–0.9% in the US, 0.9% in the UK, and 4–10% in Asia and ...
Branchio-oto-renal syndrome. Branchio-oto-renal syndrome has an autosomal dominant pattern of inheritance. Branchio-oto-renal syndrome (BOR) [4][5] is an autosomal dominant genetic disorder involving the kidneys, ears, and neck. It is also known as Melnick-Fraser syndrome. [2][3]
It is called preauricular sinus which, according to the U.S. National Institutes of Health, or NIH, "generally appears as a tiny skin-lined hole or pit, often just in front of the upper ear where ...
Basal-cell carcinoma (BCC), also known as basal-cell cancer, basalioma [7] or rodent ulcer, [8] is the most common type of skin cancer. [2] It often appears as a painless raised area of skin, which may be shiny with small blood vessels running over it . [ 1 ]
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An illustration depicting primary tumor (in the form of tumor microenvironment) and the circulating tumor cells. A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics [ 1 ] from a primary tumor and is carried around the body in the blood circulation. CTCs can extravasate and become seeds for the subsequent ...
Cowden syndrome (also known as Cowden's disease and multiple hamartoma syndrome) is an autosomal dominant inherited condition characterized by benign overgrowths called hamartomas as well as an increased lifetime risk of breast, thyroid, uterine, and other cancers. [ 1 ] It is often underdiagnosed due to variability in disease presentation, but ...