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Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. [1] There are two types of ARIA: ARIA-E and ARIA-H.
“Alzheimer’s disease has a long pre-symptomatic period; Alzheimer’s-related changes take place in the brain 10, 15, even 20 years before the onset of memory and thinking symptoms.
MRI of the brain and head has multiple diagnostic usages, including identifying aneurysms, strokes, tumors and other brain injury. [30] In many diseases, such as Parkinson's or Alzheimer's, MRI is useful to help differentially diagnose against other diseases.
The study follows other research suggesting that an optical coherence tomography angiography (OCTA) scan could potentially help doctors detect signs of Alzheimer’s disease in the small veins ...
PET scans can be used to detect amyloid and tau pathologies that are indicative of Alzheimer's disease. The absence of these signals may support the diagnosis of LATE by ruling out significant amyloid or tau misfolded proteins in the brain (which would in turn indicate the presence of Alzheimer's disease). [61]
Hara said the markers of Alzheimer’s disease can begin quite early in life without the presence of typical symptoms. She pointed to a number of interesting studies of the phenomenon.
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