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Indole-3-carbaldehyde (I3A), also known as indole-3-aldehyde and 3-formylindole, is a metabolite of dietary L-tryptophan which is synthesized by human gastrointestinal bacteria, particularly species of the Lactobacillus genus.
At very low concentrations, however, it has a flowery smell, [3] and is a constituent of many perfumes. It also occurs in coal tar. It has been identified in cannabis. [4] It is the main volatile compound in stinky tofu. [5] When indole is a substituent on a larger molecule, it is called an indolyl group by systematic nomenclature.
Moreover, 3-hydroxymethyl-beta-carboline blocks the sleep-promoting effect of flurazepam in rodents and – by itself – can decrease sleep in a dose-dependent manner. [16] Another derivative, methyl-β-carboline-3-carboxylate, stimulates learning and memory at low doses but can promote anxiety and convulsions at high doses. [ 15 ]
New research links omega-6 fatty acids, commonly found in seed oils, and colon cancer growth. But there’s more to the story—and study if you read it carefully.
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Indole-3-carbinol is the subject of on-going biomedical research into its possible anticarcinogenic, [4] antioxidant, and anti-atherogenic effects. [5] Research on indole-3-carbinol has been conducted primarily using laboratory animals and cultured cells. [6] Limited and inconclusive human studies have been reported.
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Remove the baking sheet from the oven. Let the macaroons cool for 5 minutes on the baking sheet, then transfer them to a wire rack to cool completely.