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It was developed up to phase II clinical trials for the treatment of postoperative nausea and vomiting, migraine and motion sickness. It showed good results in emesis, but development was discontinued. [12] LY-303870, or lanepitant (figure 5), is an N-acetylated reduced amide of L-tryptophan that was discovered by Eli Lilly. It underwent phase ...
An antiemetic is a drug that is effective against vomiting and nausea.Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer.
Cannabinoid hyperemesis syndrome (CHS) is recurrent nausea, vomiting, and cramping abdominal pain that can occur due to prolonged, high-dose cannabis use. [4] [5]CHS is associated with frequent (weekly or more often), long-term (several months or longer) cannabis use; synthetic cannabinoids can also cause CHS.
The vomiting center of the brain refers to the groups of loosely organized neurons in the medulla that include the CTZ within the area postrema and the nucleus tractus solitarii. [2] One of the ways the chemoreceptor trigger zone implements its effects on the vomiting center is by activation of the opioid mu receptors and delta receptors. [6]
Vomiting excessive amounts of alcohol is an attempt by the body to prevent alcohol poisoning and death. Vomiting may also be caused by other drugs, such as opiates, or toxins found in some foods and plants. Food allergies and sensitivities, such as lactose intolerance, can cause vomiting. [2] Morning sickness may have a defensive purpose. One ...
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis. [9] [10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...
Vomiting is dangerous if gastric content enters the respiratory tract. Under normal circumstances, the gag reflex and coughing prevent this from occurring; however, these protective reflexes are compromised in persons who are under the influence of certain substances (including alcohol) or even mildly anesthetized.
Howard and his wife retired in 1965 and turned the business over to his oldest son, Jerry, who ran the company until 1985. Jerry was considered one of the top engine turners of his day, and along with Don Madden, ran a series of “Howards Cams Rattler” and “Howards Cams Special” top fuel cars out of the shop as test beds for new products.
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