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  2. Amiodarone - Wikipedia

    en.wikipedia.org/wiki/Amiodarone

    This study also identified that the Standardized Incidence Ratio of cancer occurrence increased significantly in males aged 20-59 and >80 years old who were exposed to a higher dose of Amiodarone in comparison to those exposed to a lower dose. This suggests that there is a dose-effect relationship. [65]

  3. Antiarrhythmic agent - Wikipedia

    en.wikipedia.org/wiki/Antiarrhythmic_agent

    Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).

  4. Amiodarone induced thyrotoxicosis - Wikipedia

    en.wikipedia.org/wiki/Amiodarone_induced_thyro...

    Amiodarone induced thyrotoxicosis (AIT) is a form of hyperthyroidism due to treatment with antiarrhythmic drug, amiodarone. Amiodarone induced thyroid dysfunction more commonly results in hypothyroidism , estimated to occur in 6-32% of patients, whereas hyperthyroidism from amiodarone use is estimated at 1-12%. [ 1 ]

  5. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]

  6. Loading dose - Wikipedia

    en.wikipedia.org/wiki/Loading_dose

    In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.

  7. Rate of infusion - Wikipedia

    en.wikipedia.org/wiki/Rate_of_infusion

    In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective. Abbreviations include K in, [1] K 0, [2] or R 0.

  8. Intraosseous infusion - Wikipedia

    en.wikipedia.org/wiki/Intraosseous_infusion

    Intraosseous infusion (IO) is the process of injecting medication, fluids, or blood products directly into the bone marrow; [1] this provides a non-collapsible entry point into the systemic venous system. [2] The intraosseous infusion technique is used to provide fluids and medication when intravenous access is not

  9. Defined daily dose - Wikipedia

    en.wikipedia.org/wiki/Defined_Daily_Dose

    If the literature recommends generally increasing from initial to maximum dose provided it is tolerated, pick the maximum dose. If the literature recommends only increasing from an initial dose if not sufficiently effective, pick the minimum dose. If there is no guidance then pick the mid point between the dose range extremes.

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