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Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease . [ 1 ]
In medicine, histiocytosis is an excessive number of histiocytes [1] (tissue macrophages), ... Various treatments exist for histiocytosis. The one selected depends on ...
Treatment is therefore based on the patient's symptoms. [1] If there is an underlying monoclonal gammopathy, it is treated according to relevant guidelines. [1] A 51-year-old with crystal-storing histiocytosis in the left upper lip and cheek had the tumor removed in 2010.
Before the Histiocyte Society classified histiocytoses in the 1980s, the condition was also known as "Histiocytosis X", where "X" denoted the then unknown cause. [9] [10] [11] It is now known as chronic multifocal Langerhans cell histiocytosis, a subtype of LCH. [3] The disease is rare. [12] Most present between the ages of two and six. [2]
Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50 years, and is twice as common in women. [ 1 ] : 718 [ 2 ] See also
Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics. [1]
Rosai–Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy or sometimes as Destombes–Rosai–Dorfman disease, [1] [2] [3] is a rare disorder of unknown cause that is characterized by abundant histiocytes in lymph nodes or other locations including the skin, sinuses, brain and heart. Individuals with the disorder ...
Progressive nodular histiocytosis is a cutaneous condition clinically characterized by the development of two types of skin lesions: superficial papules and deeper larger subcutaneous nodules. [ 1 ] : 718 Progressive nodular histiocytosis was first reported in 1978 by Taunton et al. [ 2 ] It is a subclass of non-Langerhans cell histiocytosis ...