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CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with ...
BugMeNot is an Internet service that provides usernames and passwords allowing Internet users to bypass mandatory free registration on websites.It was started in August 2003 by an anonymous person, later revealed to be Guy King, [1] and allowed Internet users to access websites that have registration walls (for instance, that of The New York Times) with the requirement of compulsory registration.
These are most likely due to the breadth of the induced T-cell activation when anti-CTLA-4 antibodies are administered by injection in the blood stream. Using a mouse model of bladder cancer, researchers have found that a local injection of a low dose anti-CTLA-4 in the tumour area had the same tumour inhibiting capacity as when the antibody ...
Ipilimumab, sold under the brand name Yervoy, is a monoclonal antibody medication that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system.
3605 16171 Ensembl ENSG00000112115 ENSMUSG00000025929 UniProt Q16552 Q62386 RefSeq (mRNA) NM_002190 NM_010552 RefSeq (protein) NP_002181 NP_034682 Location (UCSC) Chr 6: 52.19 – 52.19 Mb Chr 1: 20.8 – 20.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8 ...
Roblox is an online game platform and game creation system built around user-generated content and games, [1] [2] officially referred to as "experiences". [3] Games can be created by any user through the platform's game engine, Roblox Studio, [4] and then shared to and played by other players. [1]
B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen – DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR).