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All PDE5 inhibitors are generally well tolerated. [1] The occurrence of side effects, or adverse drug reactions (ADRs), with PDE5 inhibitors depends on the dose and type of agent. [1] Headache is a very common ADR, occurring in >10% of patients. Other common ADRs include: dizziness, flushing, dyspepsia, nasal congestion or rhinitis. [6]
PDE5 inhibitors are not routinely prescribed as first line treatment for erectile dysfunction. This is as they cause unwanted side effects like hair loss, headache, and nausea (among others). Often, erectile dysfunction can instead be treated non-pharmacologically, by identifying and addressing a psychogenic cause of the disease. [18]
[1] [4] PDE5 inhibitors increase NO and are approved for erectile dysfunction, pulmonary arterial hypertension (PAH), and benign prostatic hyperplasia, but they are less effective in patients for whom NO production is suppressed, such as people with diabetes or obesity.
Avanafil is a PDE5 inhibitor that’s less likely to cause side effects than older medications and begins working faster. However, it’s only available under the brand name Stendra, with no generic.
The most common ED medications are PDE-5 inhibitors. They work to help widen the blood vessels in your privates, allowing more blood flow for stronger and longer-lasting arousal.
The term erectile dysfunction does not encompass other erection-related disorders, such as priapism. Treatment of ED encompasses addressing the underlying causes, lifestyle modification, and addressing psychosocial issues. [4] In many instances, medication-based therapies are used, specifically PDE5 inhibitors like sildenafil. [13]
Common symptoms of allergic reaction include hives, rash, swelling of the lips, throat, and tongue, and difficulty breathing or swallowing. ... Other PDE5 inhibitors, such as sildenafil (Viagra ...
Another option for women who have SSRI-induced anorgasmia is the use of vardenafil. Vardenafil is a type 5 phosphodiesterase (PDE5) inhibitor that facilitates muscle relaxation and improves penile erection in men. However, there is controversy about the efficiency of the drug used in the reversal of female sexual dysfunction. [21]
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