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It is uncertain whether ICSI improves live birth rates or reduces the risk of miscarriage compared with ultra‐high magnification (IMSI) sperm selection. [30] A systematic meta-analysis of 24 estimates of DNA damage based on a variety of techniques concluded that sperm DNA damage negatively affects clinical pregnancy following ICSI. [31]
Pregnancy rate is the success rate for getting pregnant.It is the percentage of all attempts that leads to pregnancy, with attempts generally referring to menstrual cycles where insemination or any artificial equivalent is used, which may be simple artificial insemination (AI) or AI with additional in vitro fertilization (IVF).
The spermatozoon is selected at higher magnification; the aim of this is to improve the chance of pregnancy. The use of high magnification for morphological sperm selection prior to ICSI has been associated with higher pregnancy rates and lower miscarriage rate.
A Cochrane review found that hCG or progesterone given during the luteal phase may be associated with higher rates of live birth or ongoing pregnancy, but that the evidence is not conclusive. [68] Co-treatment with GnRH agonists appears to improve outcomes, [68] by a live birth rate RD of +16% (95% confidence interval +10 to +22%). [69]
Low birth weight. [19] In IVF and ICSI, a risk factor is the decreased expression of proteins in energy metabolism; Ferritin light chain and ATP5A1. [20] Preterm birth. Low birth weight and preterm birth are strongly associated with many health problems, such as visual impairment and cerebral palsy. Children born after IVF are roughly twice as ...
When pregnancy is desired, the eggs can be thawed, fertilized, and transferred to the uterus as embryos. The procedure's success rate varies depending on factors such as the individual's age (with higher odds of success in younger individuals), overall health, and genetic factors. The first human birth of oocyte cryopreservation was reported in ...
The history of in vitro fertilisation (IVF) goes back more than half a century. In 1959 the first birth in a nonhuman mammal resulting from IVF occurred, and in 1978 the world's first baby conceived by IVF was born. As medicine advanced, IVF was transformed from natural research to a stimulated clinical treatment.
Gianpiero D. Palermo is the developer of the revolutionary procedure known as intracytoplasmic sperm injection (ICSI) in 1991, [1] [2] which is able to overcome male infertility in many cases. Since 1993, he has been the Director of Assisted Fertilization and Andrology at The Center for Reproductive Medicine and Infertility and has led the ICSI ...