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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
The plasma protein binding of naltrexone is about 20% over a naltrexone concentration range of 0.1 to 500 μg/L. [6] [3] Its apparent volume of distribution at 100 mg orally is 16.1 L/kg after a single dose and 14.2 L/kg with repeated doses. [6]
A 2023 systematic review published in the Australian Journal of General Practice found that preliminary research into the use of low-dose naltrexone as a treatment for fibromyalgia is promising. All clinical studies examined showed statistically significant improvements in pain and pain tolerance with mild side effects, however, sample sizes ...
[1] [2] The combination of the two drugs is thought to result in a selective blockade of the KOR and hence fewer MOR activation-related concerns such as euphoria and opioid dependence.
The win gives the Fighting Irish a matchup against No. 2 Georgia in the Sugar Bowl on Jan. 1. It’ll be the fifth Sugar Bowl appearance for Notre Dame and the school’s first since 2007, when ...
John David Sinclair (March 28, 1943 – April 6, 2015) was an American scientist and researcher best known for discovering the Alcohol Deprivation Effect (ADE) and targeted pharmacological extinction, otherwise known as the Sinclair Method, as a medication treatment for Alcohol Use Disorder (AUD).
(+)-Naloxone (dextro-naloxone) is a drug which is the opposite enantiomer of the opioid antagonist drug (−)-naloxone.Unlike (−)-naloxone, (+)-naloxone has no significant affinity for opioid receptors, [1] but instead has been discovered to act as a selective antagonist of Toll-like receptor 4.
Case reports that used doses of 0.1 mg/kg (maximum of 2 mg/dose) repeated every 1–2 minutes (10 mg total dose) have shown inconsistent benefit. [28] As the doses used throughout the literature vary, it is difficult to form a conclusion regarding the benefit of naloxone in this setting. [ 29 ]