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NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [5] [6] [7] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
Histone Deacetylation Target [22] Non-Histone Deacetylation Target [22] Pathology [22] Bacteria Yeast Mouse ... Sirt2: SIRT2: Nucleus and cytoplasm: Deacetylase: Cell ...
It was also found that the H3 acetylation induced by cocaine increased Sirt1 in the nucleus accumbens. Thus, repeated cocaine use causes an increase in both Sirt1 and Sirt2. Scientists were then interested in determining how increased Sirt1 and Sirt2 affected nuclear volume because it has been previously shown that repeated cocaine use does so ...
In this case the recombination sites are slightly asymmetric, which allows the enzyme to tell apart the left and right ends of the site. When generating products, left ends are always joined to the right ends of their partner sites, and vice versa. This causes different recombination hybrid sites to be reconstituted in the recombination products.
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. [1] [2] [note 1] Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.
Site saturation mutagenesis is a type of site-directed mutagenesis. This image shows the saturation mutagenesis of a single position in a theoretical 10-residue protein. The wild type version of the protein is shown at the top, with M representing the first amino acid methionine, and * representing the termination of translation.
Tournament rules including for gender issues at Olympic boxing are broadly the same as at the 2016 Rio de Janeiro Games, though the IOC on Monday cited career records of the two women targeted by ...
In genetics, Flp-FRT recombination is a site-directed recombination technology, increasingly used to manipulate an organism's DNA under controlled conditions in vivo.It is analogous to Cre-lox recombination but involves the recombination of sequences between short flippase recognition target (FRT) sites by the recombinase flippase (Flp) derived from the 2 μ plasmid of baker's yeast ...