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NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [ 5 ] [ 6 ] [ 7 ] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
Joker: Folie à Deux [a] is a 2024 American jukebox musical [10] legal drama film directed by Todd Phillips from a screenplay he co-wrote with Scott Silver.Based on DC Comics characters, it is the sequel to Joker (2019) and stars Joaquin Phoenix reprising his role as Arthur Fleck / Joker, alongside Lady Gaga as Harley "Lee" Quinzel.
It is the first Korean film to do so in 2025 at the box office. [12] On February 3, it crossed 2 million viewers on 13th day of its release. [13] As of February 20, 2025, the film has grossed US$16,390,976 from 2,497,051 admissions making it the top-grossing Korean film of 2025 at the South Korean box office. [9] [1]
In yeast, roundworms, and fruitflies, sir2 is the name of one of the sirtuin-type proteins (see table below). [16] Mammals possess seven sirtuins (SIRT1–7) that occupy different subcellular compartments: SIRT1, SIRT6 and SIRT7 are predominantly in the nucleus, SIRT2 in the cytoplasm, and SIRT3, SIRT4 and SIRT5 in the mitochondria. [2]
Move over, Wordle, Connections and Mini Crossword—there's a new NYT word game in town! The New York Times' recent game, "Strands," is becoming more and more popular as another daily activity ...
Here are some of the energy-related executive orders Trump could announce during his first days in office, as he seeks to follow through on that promise. Trump could order the U.S. to withdraw ...
Revenue rose 16% over the same time a year ago, to $10.2 billion, compared with Wall Street's estimates of $10.1 billion for the quarter, according to LSEG. The jump in subscribers in the quarter ...
Ad Vitam is a 2025 French action thriller film directed by Rodolphe Lauga and starring Guillaume Canet, who also co-wrote the film with Lauga and David Corona. It was released globally on Netflix on 10 January 2025.