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Sertraline appears to work better in melancholic depression than fluoxetine, paroxetine, and mianserin and is similar to the tricyclic antidepressants such as amitriptyline and clomipramine. [32] In the treatment of depression accompanied by OCD , sertraline performs significantly better than desipramine on the measures of both OCD and depression.
PE is one of the most common forms of dysfunction, affecting about 20 to 30 percent of men who are active (although reports are very subjective, so the true prevalence might be higher or lower).
Zoloft is often prescribed off-label to treat PE, because it can make climaxing take longer. Zoloft works by increasing serotonin levels, which can cause side effects such as difficulty with ...
Some antidepressants, including sertraline (Zoloft) and paroxetine (Paxil) are used off-label to treat PE. Research shows that these medications help slow down climax and improve stamina for men ...
[187] [188] Fluvoxamine is an agonist of the σ 1 receptor, while sertraline is an antagonist of the σ 1 receptor, and paroxetine does not significantly interact with the σ 1 receptor. [ 187 ] [ 188 ] None of the SSRIs have significant affinity for the σ 2 receptor .
He pointed out that the first-line alternative to medication is psychotherapy, which does not have superior efficacy. [105] Antidepressants in general are as effective as psychotherapy for major depression, and this conclusion holds true for both severe and mild forms of MDD. [106] [107] In contrast, medication gives better results for dysthymia.
Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram). Effectiveness and side effect rates can vary between SSRIs. Effectiveness and side effect rates can vary ...
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).