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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
The one biomarker that has been in use over the last 20 years is CA-125. [121] A 2016 review found that this biomarker was present in those with symptoms of endometriosis; and, once ovarian cancer has been ruled out, a positive CA-125 may confirm the diagnosis. [122] Its performance in ruling out endometriosis is low. [122]
While estimates vary widely, [39] [40] eating disorders are estimated to affect as high as 13% of women in some age groups [41] [42] [43] and 3% of men in Western cultures, with anorexia nervosa affecting 10 women for each man and bulimia nervosa affecting 8 women for each man. [44] Alzheimer's disease has a higher incidence in females compared ...
In addition, some values, including troponin I and brain natriuretic peptide, are given as the estimated appropriate cutoffs to distinguish healthy people from people with specific conditions, which here are myocardial infarction and congestive heart failure, respectively, for the aforementioned substances.
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Approximately 50% of women over 40 years of age Moderate to severe myeloneuropathy Similar to male AMN phenotype, but later onset and milder presentation Adulthood Approximately 15% of women over 40 years of age Cerebral involvement Progressive dementia and decline Rare in childhood, more common in adults ~2% Adrenal involvement
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The condition is more common in older adults. [5] CPPD is estimated to affect 4% to 7% of the adult populations of Europe and the United States. [16] Previous studies have overestimated the prevalence by simply estimating the prevalence of chondrocalcinosis, which is found in many other conditions as well. [16]