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Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. [1] The second one was apixaban (Eliquis), approved in Europe in 2011 [2] and in the United States in 2012. [3] The third one edoxaban (Lixiana, Savaysa) was approved in Japan in 2011 and in Europe and the US in 2015. [4]
Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 28 ]
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
Ratings are updated yearly, but data is two years old before Medicare releases it. [1] [18] [19] Healthgrades develops objective ratings based on data and information from several publicly available sources. [18] The data is analyzed using a proprietary methodology that identifies the recipients of the various awards and the "1-3-5 Star ...
This list compiles the names of neurologists and neurosurgeons with a corresponding Wikipedia biographical article, and is not necessarily a reflection of their relative importance in the field. Many neurologists and neurosurgeons are considered to be neuroscientists as well and some neurologists are also in the list of psychiatrists.
For a list sorted by facility name see List of hospitals in Alberta. Banff. Banff Mineral Springs Hospital; Bassano. Bassano Health Centre; Calgary. Alberta Children's Hospital (ACH) Foothills Medical Centre (FMC) Peter Lougheed Centre (PLC) Rockyview General Hospital (RGH) Sheldon M. Chumir Centre; South Health Campus (SHC) Tom Baker Cancer ...
RateMDs.com is a free website allowing users to submit and read reviews of doctors, dentists, psychologists, urgent care centers, group practices, hospitals and other healthcare facilities. Founded in 2004, it has gained popularity as a platform for patients to research and share their experiences about healthcare providers.
Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]