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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
Cervical squamous intraepithelial lesion (SIL), previously called cervical intraepithelial neoplasia (CIN), is a form of dysplasia that can progress to cervical cancer. The term carcinoma in situ may be used interchangeably with high-grade SIL. [8] Ductal carcinoma in situ of the breast is the most common precancer in women.
When CIN3 lesions lead to cancer, most of them have the assistance of the HPV virus, but that is not always the case, which is why it can be considered a direct link to cervical cancer. [55] Heavy smoking and long-term smoking seem to have more of a risk of getting the CIN3 lesions than lighter smoking or not smoking at all. [56]
For premalignant dysplastic changes, the CIN (cervical intraepithelial neoplasia) grading system is used. [7] Colon cancer: originally consisted of four stages: A, B, C, and D (the Dukes staging system). More recently, colon cancer staging is indicated either by the original A-D stages or by TNM. [8] Kidney cancer: uses TNM. [9]
The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), [1] cervical smear (BE), cervical screening (BE), [2] or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or, more rarely, anus (in both men and women). [3]
This is a list of well-known dimensionless quantities illustrating their variety of forms and applications. The tables also include pure numbers, dimensionless ratios, or dimensionless physical constants; these topics are discussed in the article.
Chart Information Network, now known as the Official Charts Company; Children in Need, an annual UK Telethon Fundraiser shown on the BBC; The Crime & Investigation Network; The Caribbean International Network (CIN TV)
The curie (symbol Ci) is a non-SI unit of radioactivity originally defined in 1910. According to a notice in Nature at the time, it was to be named in honour of Pierre Curie , [ 1 ] but was considered at least by some to be in honour of Marie Curie as well, [ 2 ] and is in later literature considered to be named for both.