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Fetal hydantoin syndrome, also called fetal dilantin syndrome, is a group of defects caused to the developing fetus by exposure to teratogenic effects of phenytoin. Dilantin is the brand name of the drug phenytoin sodium in the United States, commonly used in the treatment of epilepsy .
During the third stage of development (weeks 5-6) in the mother dog's womb, the fetus starts to rapidly grow and features like the feet and nails are developed. If there is any defect within the development at this stage, it can cause the paw pads to only partially separate resulting in the "cloven" look.
Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. [174] Ibuprofen * can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. [175] Naproxen (Aleve)* has a long half-life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting.
The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study showed that most blood concentrations in breastfed infants of mothers taking carbamazepine, oxcarbazepine, valproate, levetiracetam, and topiramate were quite low, especially in relationship to the mother's level and what the fetal level would have been ...
Teratogens are substances that may cause non-heritable birth defects via a toxic effect on an embryo or fetus. [1] Defects include malformations, disruptions, deformations, and dysplasia that may cause stunted growth, delayed mental development, or other congenital disorders that lack structural malformations. [2]
Some of the more common possible causes of fading puppy syndrome are: Hypothermia and hyperthermia [3] Lack of adequate care from the mother [2] [3] Congenital defects [2] [3] Low birth weight [3] Infection or disease [3] After birth, the majority of the puppy's immune system is gained through the colostrum, or first milk. If the puppy is ...
Birth defects are divided into two main types: structural disorders in which problems are seen with the shape of a body part and functional disorders in which problems exist with how a body part works. [3] Functional disorders include metabolic and degenerative disorders. [3] Some birth defects include both structural and functional disorders. [3]
Some medications are associated with birth defects when used in pregnancy. [106] Many of the common used medications, such as valproate, phenytoin, carbamazepine, phenobarbital, and gabapentin have been reported to cause increased risk of birth defects, [158] especially when used during the first trimester. [159]