Search results
Results from the WOW.Com Content Network
Structure of the classical cephalosporins. The cephalosporins (sg. / ˌ s ɛ f ə l ə ˈ s p ɔːr ɪ n, ˌ k ɛ-,-l oʊ-/ [1] [2]) are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as Cephalosporium. [3] Together with cephamycins, they constitute a subgroup of β-lactam antibiotics ...
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or streptococcal tonsillitis, urinary tract infection, reproductive tract infection, and skin infections.
Cephems are a sub-group of β-lactam antibiotics including cephalosporins and cephamycins. [1] It is one of the most common 4-membered ring heterocycle. [ 2 ] Produced by actinomycetes, cephamycins were found to display antibacterial activity against a wide range of bacteria, including those resistant to penicillin and cephalosporins. [ 3 ]
Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v. Cefonicid synthesis: [2] [3] [4] Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of cefamandole.
Cefalotin / ˌ s ɛ f ə ˈ l oʊ t ɪ n / or cephalothin / ˌ s ɛ f ə ˈ l oʊ θ ɪ n / is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity. [1] [2] It was the first cephalosporin marketed (1964) and continues to be widely used. [3]
Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972.It was synthesized in order to create an antibiotic with a broader spectrum. [4]
Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g. penicillins, carbapenems and monobactams). [1] The cephalosporins (and other β-lactams) have the ability to kill bacteria by inhibiting essential steps in ...