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Golgi's methodis a silver stainingtechnique that is used to visualize nervous tissueunder light microscopy. The method was discovered by Camillo Golgi, an Italianphysicianand scientist, who published the first picture made with the technique in 1873.[1] It was initially named the black reaction(la reazione nera) by Golgi, but it became better ...
Camillo Golgi (Italian: [kaˈmillo ˈɡɔldʒi]; 7 July 1843 – 21 January 1926) was an Italian biologist and pathologist known for his works on the central nervous system. He studied medicine at the University of Pavia (where he later spent most of his professional career) between 1860 and 1868 under the tutelage of Cesare Lombroso.
The Golgi apparatus (/ ˈɡɒldʒi /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [ 1 ] Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.
In the vesicle, more parts are cut off, and it turns into mature insulin. In molecular biology, post-translational modification (PTM) is the covalent process of changing proteins following protein biosynthesis. PTMs may involve enzymes or occur spontaneously. Proteins are created by ribosomes, which translate mRNA into polypeptide chains, which ...
Pyramidal cells are the primary excitation units of the mammalian prefrontal cortex and the corticospinal tract. One of the main structural features of the pyramidal neuron is the conic shaped soma, or cell body, after which the neuron is named. Other key structural features of the pyramidal cell are a single axon, a large apical dendrite ...
Camillo Golgi perfected the silver staining for the study of the nervous system. Golgi's method stains a limited number of cells at random in their entirety. [29] Autoradiography, also used for protein band detection post gel electrophoresis, uses radioactive isotopes to label proteins, which are then detected by using X-ray film. [30]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. [ 6 ]
Donald Kent Morest (October 4, 1934 – December 30, 2020) was an American educator and researcher. He is regarded as "the father of modern neuroanatomy of the auditory system.". [1] His unconventional use of Golgi methods to study the neuroanatomy of the auditory nervous system in humans and mammals laid the foundation for investigations into ...