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Giant cell arteritis and its treatment impact on people's lives because of symptoms, adverse effects of GCs and disruption to normal life. [38] People with GCA have previously ranked ‘losing sight in both eyes permanently’, ‘having intense or severe pain’ and ‘feeling weak, tired or exhausted’ as important quality of life domains ...
Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), [1][2][3][4][5] after the German physician Friedrich Wegener, is a rare long-term systemic disorder that involves the formation of granulomas and inflammation of blood vessels (vasculitis). It is an autoimmune disease and a form of vasculitis that affects ...
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Arteritis. Arteritis is a vascular disorder characterized by inflammation of the walls of arteries, [1] usually as a result of infection or autoimmune responses. Arteritis, a complex disorder, is still not entirely understood. [2] Arteritis may be distinguished by its different types, based on the organ systems affected by the disease. [2]
The disease's symptoms can range from catastrophic neurological impairment to an asymptomatic condition brought on by impalpable pulses or bruits. [7] Non-specific features include mild anemia, myalgia, arthralgia, weight loss, malaise, night sweats, and fever. [8] Giant cell arteritis (GCA) is the most common type of systemic vasculitis in adults.
AAION is due to temporal arteritis (also called giant-cell arteritis), an inflammatory disease of medium-sized blood vessels (Chapel-Hill-Conference) that occurs especially with advancing age. In contrast, NAION results from the coincidence of cardiovascular risk factors in a patient with "crowded" optic discs.
Main symptoms Primary large vessel vasculitis [8] Takayasu arteritis: Diminished or absent pulses, vascular bruits, hypertension, Takayasu retinopathy, and aortic regurgitation. [9] Giant cell arteritis: Headache, scalp tenderness, jaw claudication, and blindness. [10] Primary medium vessel vasculitis [8] Polyarteritis nodosa
Specialty. Immunology, rheumatology. Polyarteritis nodosa (PAN) is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation. [3] Small aneurysms are strung like the beads of a ...
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