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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38, [7] which is overexpressed in multiple myeloma cells. [8]
Mantle cell lymphoma (MCL) is a rare form of cancerous B-cell non-Hodgkin's lymphoma that usually occurs in middle-aged or older adults. [10] In people with MCL, B-cells , a type of white blood cell which help the body fight infection, change into cancer cells that start to form tumors in the lymph nodes and quickly spread to other areas of the ...
It acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. After intravenous infusion it is extensively metabolised in the liver by cytochrome p450. More than 95% of the drug is bound to protein – primarily albumin. Only free bendamustine is active.