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Microangiopathy (also known as microvascular disease, small vessel disease (SVD) or microvascular dysfunction) is a disease of the microvessels, small blood vessels in the microcirculation. [1] It can be contrasted to macroangiopathies such as atherosclerosis , where large and medium-sized arteries (e.g., aorta , carotid and coronary arteries ...
In diseases such as hemolytic uremic syndrome, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and malignant hypertension, the endothelial layer of small vessels is damaged with resulting fibrin deposition and platelet aggregation.
There are two types of angiopathy: macroangiopathy and microangiopathy. [2] In macroangiopathy, atherosclerosis and a resultant blood clot forms on the large blood vessels, sticks to the vessel walls, and blocks the flow of blood. Macroangiopathy in the heart is coronary artery disease; in the brain, it is cerebrovascular disease.
Named after the Dutch mathematician Bartel Leendert van der Waerden, the Van der Waerden test is a statistical test that k population distribution functions are equal. The Van der Waerden test converts the ranks from a standard Kruskal-Wallis test to quantiles of the standard normal distribution (details given below).
The term normal score is used with two different meanings in statistics. One of them relates to creating a single value which can be treated as if it had arisen from a standard normal distribution (zero mean, unit variance). The second one relates to assigning alternative values to data points within a dataset, with the broad intention of ...
Thrombotic microangiopathy (TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury. [1] It may be seen in association with thrombocytopenia , anemia , purpura and kidney failure .
Medical calculators arose because modern medicine makes frequent use of scores and indices that put physicians' memory and calculation skills to the test. [2] The advent of personal computers, the Internet and Web, and more recently personal digital assistants (PDAs) have formed an environment conducive to their development, spread and use.
Compared to the National Early Warning Score from the UK, Q-ADDS had a higher rate of prediction of deterioration (46.5% Q-ADDS vs 40.8% NEWS) but a higher rate of false-positives (3.2:1 Q-ADDS vs 2.4:1 NEWS). [12] The efficacy of EWSs in improving patient outcomes is also reliant on a number of personal and structural factors.