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The old trained men have succinate dehydrogenase activities within their type IIa muscle fibers similar to those in young men and twofold higher than in old normal fit men. [ 20 ] Neural changes like reduced motor unit discharge rates, increased variability of motor unit discharge activity, altered recruitment and derecruitment behavior mediate ...
Encephalitis lethargica is an atypical form of encephalitis.Also known as "sleeping sickness" or "sleepy sickness" (distinct from tsetse fly–transmitted sleeping sickness), it was first described in 1917 by neurologist Constantin von Economo [2] [3] and pathologist Jean-René Cruchet. [4]
As of 2016, the International Society for the Study of the Aging Male defines late-onset hypogonadism as a series of symptoms in older adults related to testosterone deficiency that combines features of both primary and secondary hypogonadism; the European Male Aging Study (a prospective study of ~3000 men) [10] defined the condition by the presence of at least three sexual symptoms (e.g ...
In the elderly, hypoglycemia can produce focal stroke-like effects or a hard-to-define malaise. [medical citation needed] The symptoms of a single person do tend to be similar from episode to episode. In the large majority of cases, hypoglycemia severe enough to cause seizures or unconsciousness can be reversed without obvious harm to the brain.
Chronic fatigue with a known cause is twice as common as idiopathic chronic fatigue. [6] Idiopathic chronic fatigue affects between 2.4% and 6.42% of patients, [26] with females more likely to be affected than men. [1] Age at onset is typically over 50 years of age. [13]
Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.
Fatigue in a medical context is used to cover experiences of low energy that are not caused by normal life. [2] [3]A 2021 review proposed a definition for fatigue as a starting point for discussion: "A multi-dimensional phenomenon in which the biophysiological, cognitive, motivational and emotional state of the body is affected resulting in significant impairment of the individual's ability to ...
Lethargy is a state of tiredness, sleepiness, weariness, fatigue, sluggishness, or lack of energy. It can be accompanied by depression , decreased motivation, or apathy . Lethargy can be a normal response to inadequate sleep, overexertion, overworking, stress, lack of exercise, improper nutrition, drug abuse, boredom , or a symptom of an ...