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The aims of EULAR are to reduce the burden of rheumatic diseases on the individual and society and to improve the treatment, prevention and rehabilitation of musculoskeletal diseases. It promotes the translation of research advances into daily care and fights for the recognition of the needs of people with musculoskeletal diseases by the ...
Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )
Epratuzumab binds to the glycoprotein CD22 of mature and malignant B-cells.. Elevated CD22 and other B-cell receptor (BCR) proteins are associated with SLE. "Epratuzumab's mechanism of action transfers these BCR proteins to helper cells called effector cells which reduces B-cell destruction and epratuzumab's impact on the body's immune system" [6] via a process called trogocytosis. [3]
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases. [3] [4] It is a type of glomerulonephritis in which the glomeruli become inflamed.
Children up to 18 years old develop a more severe form of SLE termed childhood-onset systemic lupus erythematosus. [4] The cause of SLE is not clear. [1] It is thought to involve a combination of genetics and environmental factors. [5] Among identical twins, if one is affected there is a 24% chance the other one will also develop the disease. [1]
[1] RA affects about 24.5 million people as of 2015. [10] This is 0.5–1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. [3] Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. [1]
ACR score is a scale to measure change in rheumatoid arthritis symptoms. [1] It is named after the American College of Rheumatology.The ACR score is more often used in clinical trials than in doctor patient-relationships, as it allows a common standard between researchers.
The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a physician and practicing histologist at the Mayo Clinic. [5] Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with ...